Benzyl Isothiocyanate Suppresses the Invasion and Angiogenesis of U87MG Human Glioma Cells

Glioma is one of the most common cancer worldwide and most patients present with metastasis disease at diagnosis time. Therefore, metastasis management is of great importance to the clinical therapeutics. Metastasis is a complex process, such as loss of cellular adhesion, increased invasiveness, entried to circulation, colonized into new tissue, and developed to metastasis site by cell adhesion molecules, extracellular matrix protein and tumor-related gene (Fidler, 2011). Recent studies showed that edible cruciferous plants, such as broccoli, cabbage and water celery, could reduce the risk of cancer. Benzyl isothiocyanate (BITC) is an active compound in edible cruciferous plants and it is showed anti-tumor activity in many types of tumor (Zhu et al, 2013). In this study, we focused on BITC and investigated its inhibitory effects on glioma U87 MG cell metastasis potential, and explored effects on U87 cell invasion and angiogenesis and related mechanisms.